Yes! Just like any other organism, each strain of psilocybin mushroom has its own unique makeup. This means that each strain can have different effects on the body and mind. Some people find that certain strains are more potent than others, while some people find that certain strains produce different types of hallucinations.
The risk of contamination amongst different strains also varies. Some strains, like B+ mushrooms, are more resistant to contaminants than others.