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Exploring the Science Behind Magic Mushrooms

Magic Mushrooms

What makes mushrooms so fascinating? Well, for starters, fungi are an ancient life form. And, in-depth research into their microbiology suggests that on a DNA level, they share certain common elements with humans.

Of the approximately 148,000 known species of fungi, only a select few contain the substance psilocybin. These are commonly referred to as ‘magic mushrooms’ in scientific studies due to their unique biochemical properties. It’s interesting to note that the study of fungi, or mycology, offers insights into various species, including those with unique biochemical compositions.

Mycology is a branch of microbiology where researchers delve into the complex world of mushrooms, contributing to our understanding of their ecological roles and biological structures. In the following sections, we explore the fascinating structure and biological aspects of various fungi, providing an educational perspective on their place in the natural world.

Understanding Magic Mushrooms 

What are magic mushrooms? These naturally occurring fungi are part of the higher fungi category, known for their unique sporocarp, or fruiting body. They emerge from an extensive, root-like network called mycelium. This mycelium network, predominantly underground or within the substrate, consists of filament fibers known as hyphae. The visible mushroom is just a small, above-ground component of the larger fungal organism. The key distinction between magic mushrooms and the varieties found in grocery stores lies in their chemical composition. Let’s delve into the fascinating structure and unique biochemical makeup of these mushrooms.

Mushroom Structure 

The physical attributes differ among mushrooms, but certain parts are common in most species:

  • Pileus: The cap-like part that supports the spore-bearing surface. These can take various shapes and even structure changes as the fungus transitions through developmental stages. The most common structures are convex and flat ones.
  • Stipus: The stalk that holds up the cap.
  • Volva: Also known as the universal veil, this cup houses the immature fruiting body, and the mushroom sprouts from this structure.
  • Annulus: A ring of tissue below the cap’s gills is commonly called the partial veil.
  • Lamellae (gills): These are the thin ribbon-like projections at the underside of the pileus. In some cases, this is the site of spore production.
  • Mycelium: The fungal hyphae is a mass of fibers that spreads to collect nutrients.

mushrooms perched on a log

Mycology enthusiasts can identify most of these parts with the naked eye. However, an in-depth study of mycelium and spores requires a microscope. This is where microbiology comes into play. Fungal spores are little particles. They’re the reproductive elements of the mushroom that the fruiting body releases. They spread by wind or other methods until they land on a suitable substrate to start forming mycelium. To accurately identify a species, mycologists need to observe its microscopic features. Common elements that they check include the spore-producing tissue (hyphal tissue), the spore cells’ shape and size, and the spore color from a spore print.

Magic mushroom graphic artwork

Chemical Composition 

The chemical composition of fungi is incredibly complex, featuring a range of unique compounds.

Psilocybin and Psilocin 

Among these, psilocybin stands out as a notable compound found in several mushroom species. This substance undergoes a transformation into psilocin, which is essential for its active role in these fungi.

The transformation from psilocybin to psilocin is a key biochemical process in these mushrooms. Structurally, psilocin shares similarities with certain naturally occurring compounds, highlighting the intricate chemistry of these organisms.

Nor Psilocin 

Derived from psilocybin, researchers believe that this compound is a potent dephosphorylated form of baeocystin. It was only discovered in 2017 and required further study to reveal its impact.


Like nor psilocin, this chemical also requires further study. Getting the compound in its pure form is challenging, which is a significant hindrance to understanding it better. Current research suggests that baeocystin has psychoactive effects. Some reports assert that it may be equally as potent as psilocybin. 

Nor Baeocystin

Nor baeocystin is a lesser-known compound found in many magic mushrooms. It is derived from baeocystin and related to 4-hydroxytryptamine. While there is some discussion in scientific circles about the potential non-psychedelic properties of norbaeocystin, these are not yet confirmed. Research is ongoing to understand its role, including the possibility of it being a part of the biosynthesis process of psilocybin in fungi.


Aeruginascin, a compound found in some magic mushrooms, shares a similar chemical structure with psilocybin. While research on aeruginascin is still in its early stages, its unique composition has led to theories about its behavior in the body. One such theory suggests that aeruginascin may not cross from the bloodstream into the brain as readily as other compounds. Additionally, researchers are exploring the idea that aeruginascin needs to undergo demethylation, a metabolic process, to become active in the body.


B-carbolines have been identified in certain mushroom species. Current research suggests that these chemicals might play a role in the overall biochemical makeup of these fungi. While there is some evidence pointing towards their potential influence on the properties of these mushrooms, further research is needed to fully understand their specific role and effects.

Magic Mushrooms in a Minute

Magic mushrooms, with their intricate structures and diverse forms, have long intrigued scientists and captivated human curiosity. These fungi possess an extensive underground network of mycelium, a remarkable adaptation that allows them to absorb nutrients from decaying organic matter. Despite their diverse appearances, different species of magic mushrooms share commonalities in their underlying structure and chemical composition. These unique characteristics continue to inspire ongoing research to fully understand the potential benefits and potential risks associated with these fungi. If you’re interested in delving deeper into mushroom microbiology, consider ordering a mycological sample from our shop to learn more about these magnificent fungi.

All of the content and images on our site are for informational reference only. The cultivation of psilocybin mushrooms is federally illegal in the United States. We do not promote the cultivation of psilocybin “magic” mushrooms under any circumstances. Do not contact us asking for advice related to this subject. Any products found on this site are for microscopy and taxonomy purposes only.

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